Abstract: This systematic literature review synthesizes findings from 46 studies examining the lived experiences, stressors, and support systems of mothers raising children with autism spectrum disorder (ASD) across diverse cultural contexts. Mothers of children with ASD face heightened psychological stress and caregiving burden, often intensified by social stigma, financial strain, and insufficient institutional support. Family and spousal support consistently emerged as key protective factors, mitigating depressive symptoms and emotional exhaustion (Nirbhay N. Singh G. E.‐S., 2020) (Prinu Jose, 2018) (Yulina Eva Riany, 2021). While formal support systems such as schools and health services were frequently reported as inadequate, especially during crises like the COVID-19 pandemic (Roberto Marcone, 2023), community-based interventions, such as inclusive music programs, promoted social engagement and emotional relief (Miriam D. Lense, 2020). Online platforms, particularly social media, provided mothers with emotional validation and shared knowledge in low-resource settings (Siti Hajar Mohd Roffeei, 2015). Additionally, psychological resilience, self-compassion, and perceived social support were closely associated with posttraumatic growth (Mona Tawakkul Ebrahim, 2021) (Buchhol, 2023). Crucially, the presence of services alone did not ensure positive outcomes; the emotional quality and relevance of those supports played a determining role (Jocelyn Kuhn, 2017). The findings highlight the need for multi-layered, culturally sensitive support systems for maternal caregivers in neurodiverse families.