Development of cotton gauze with nanoparticle from Pomegranate peel extract for diabetic foot ulcers
Author(s): 1. Hemalatha.P, 2. Shathiyaa priyaa.C.L
Authors Affiliations:
1.Post graduate,Department of Microbiology, Tiruppur Kumaran College for Women, Tirupur, India.
2.Assistant Professor , Department of Microbiology, Tiruppur Kumaran College for Women, Tirupur, India
DOIs:10.2017/IJRCS/202505014 | Paper ID: IJRCS202505014Abstract: People with diabetes will develop foot ulcers due to neuropathy (sensory, motor and autonomic deficits), ischaemia, or both. The initiating injury may be from mechanical or thermal trauma or from repetitively or continuously applied mechanical stress. Pomegranate belongs the family of Punicaceae. It has delicious shrubs. Pomegranate is used as food and plays a vital role in the medicinal field. Because pomegranate fruit and its peel extraction contain various compounds like antioxidant, phenolic acid, Flavonoids, Tannins etc., that have been found very effective in the health field. This study about the pomegranate (Punica granatum) peel has the ability to heal the diabetic foot ulcers because of its compounds. It was tested by some of the Laboratory techniques such as phytochemical analysis, anti inflammatory, antioxidant activity, TLC, UV Spectroscopy, FTIR Spectroscopy and antimicrobial activity. To enhance the anti inflammatory, antioxidant and antimicrobial activity silver nanoparticle (AgNP3) was added and it given the effective result than the Pomegranate (Punica granatum) peel extract alone. Formulation of combine sterile cotton gauze with Pomegranate (Punica granatum) peel extract and nanoparticle (AgNP3) enhanced antimicrobial properties and faster the wound healing. Pomegranate (Punica granatum) peel extract and nanoparticle (AgNP3) have regenerative effects of tissue-stimulating potential and reduced in infection risk. Nanoparticle prevents bacterial growth, keeping the diabetic foot ulcer environment sterile.
Hemalatha.P, Shathiyaa priyaa.C.L (2025); DEVELOPMENT OF COTTON GAUZE WITH NANOPARTICLE FROM POMEGRANATE PEEL EXTRACT FOR DIABEIC FOOT ULCERS, International Journal of Research Culture Society, ISSN(O): 2456-6683, Volume – 9, Issue – 5, Pp.84-92. Available on – https://ijrcs.org/
Reference
1.International Diabetes Federation. (2019). IDF Diabetes Atlas (9th ed.). International Diabetes Federation.
2.Kumar, S., Singh, V., Johar, V., Varma, S., Thakur, R., & Banerjee, D. (2023). Antioxidant activity, antibacterial activity, and phenolic composition of pomegranate fruit. Journal of Food Chemistry & Nanotechnology.
3.Jayaprakash, A., & Sangeetha, R. (2015). Phytochemical screening of Punica granatum Linn. peel extracts. Journal of Academia and Industrial Research (JAIR).ISSN:2278-5213
4.Dikmen, M., Ozturk, N., & Ozturk, Y. (2011). The antioxidant potency of Punica granatum L. fruit peel reduces cell proliferation and induces apoptosis in breast cancer. Journal of Medicinal Food, 14(12), 1638–1646.
5.Pinnamaneni, R. (2018). Preliminary phytochemical investigation of the peel of pomegranate (Punica granatum L.). Research Journal of Pharmacy and Technology. ISSN 0974-3618,0974-360X
6.Nisha, M. H., Tamileaswari, R., & Jesurani, S. S. (2015). Analysis of antibacterial activity of silver nanoparticles from pomegranate (Punica granatum) seed and peel extracts. International Journal of Engineering Research & Technology (IJERT), 4(4).ISSN:2278-0181
7.Vinay, C. H., Goudanavar, P., & Acharya. (2018). Development and characterization of pomegranate and orange fruit peel extract-based silver nanoparticles. Journal of Nanotechnology and Materials Science, 4(1).ISSN:2091-1041
8.Zam, W., Harfouch, R., Ali, R., Atfah, Y., & Mousa, A. (2018). Natural extracts and honey-based impregnated gauze wound dressing preparation and in vitro antibacterial efficacy. Research Journal of Pharmacognosy and Phytochemistry.ISSN:0975-2331,0975-4385
9.Khan, J. A., & Hanee, S. (2011). Antibacterial properties of Punica granatum peels. International Journal of Applied Biology and Pharmaceutical Technology.ISSA 096-45507
10.Jaswal, P., AgyaPreet, A., Simran, S., & Goel, G. (2017). Antimicrobial activity of herbal treated cotton fabric. International Research Journal of Engineering and Technology (IRJET), 4(7), [page numbers if available]. https://www.irjet.net/ (if applicable)